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;In vivo: MK-4827 is very well tolerated in vivo and demonstrates efficacy as just one agent in a xenograft product of BRCA-1 deficient most cancers [1]. On top of that, MK-4827 strongly enhances the impact of radiation on various human tumor xenografts, both of those p53 wild form and p53 mutant. The improvement of radiation response is observed i

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